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ARK Therapeutic Drug Monitoring** Gabapentin With placebo very low quality Nineteen participants 8000 mg gabapentin the study because of adverse events: 12 in the gabapentin group 16% and 7 in the 8000 mg gabapentin group 9% very low quality The number of serious adverse events were not reported, and no deaths were reported very low quality ottom line There is moderate-quality evidence that oral gabapentin at doses of 1200 mg daily or more has an important effect on pain in some people with 8000 mg gabapentin or severe neuropathic pain after shingles or due to diabetes.
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|Trade names||Neurontin, others |
|License data||US DailyMed: 52049, US FDA: Gabapentin|
|Pregnancy category||AU: B1 US: C (Risk not ruled out)|
|Routes of administration||By mouth|
|ATC code||N03AX12 ( WHO )|
|Legal status||AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only|
|Bioavailability||27–60% (inversely proportional to dose; a high fat meal also increases bioavailability)  |
|Protein binding||Less than 3%  |
|Metabolism||Not significantly metabolized  |
|Elimination half-life||5 to 7 hours  |
|Excretion||Renal  |
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